This site is intended for healthcare professionals
Journals
  • Home
  • /
  • Journals
  • /
  • Solid Organ Transplantation
  • /
  • The Emerging Role of Regulatory T Cells Following ...
Journal

The Emerging Role of Regulatory T Cells Following Lung Transplantation

Read time: 1 mins
Published:31st Oct 2019
Author: Gauthier JM, et al.
Ref.:Immunol Rev. 2019;292(1):194‐208.
DOI:10.1111/imr.12801
The emerging role of regulatory T cells following lung transplantation


Regulatory T cells (Treg) have proven to be a powerful immunologic force in nearly every organ system and hold therapeutic potential for a wide range of diseases. Insights gained from non‐transplant pathologies, such as infection, cancer, and autoimmunity, are now being translated to the field of solid organ transplantation, particularly for livers and kidneys. Recent insights from animal models of lung transplantation have established that Tregs play a vital role in suppressing rejection and facilitating tolerance of lung allografts, and such discoveries are being validated in human studies and preclinical trials. Given that long‐term outcomes following lung transplantation remain profoundly limited by chronic rejection, Treg therapy holds the potential to significantly improve patient outcomes and should be aggressively investigated.


Read abstract on library site Access full article