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Natural course of acquired vitelliform lesions associated with pigment epithelial detachments in dry age related macular degeneration

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Published:27th Jan 2021
Author: Yanık Ö, Demirel S, Batıoğlu F, Özmert E.
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Ref.:Eur J Ophthalmol. 2021 Jan 28:1120672121990566.
DOI:10.1177/1120672121990566
Natural course of acquired vitelliform lesions associated with pigment epithelial detachments in dry age related macular degeneration


Purpose: To describe the natural history of acquired vitelliform lesions (AVLs) associated with different types of pigment epithelial detachments (PEDs) in dry age-related macular degeneration.

Methods: A retrospective review of clinical examination and multimodal imaging data of patients with AVLs associated with PED(s) was performed.

Results: This study included 25 eyes of 17 patients. The mean age of patients was 67.2 ± 9.7 (47-83) years. The mean follow-up time was 32.6 ± 16.2 (12-66) months, excluding four patients (five eyes) that were lost to follow-up. The mean logMAR BCVA was 0.21 ± 0.16 at baseline and 0.38 ± 0.28 at final visit (p = 0.016). At the end of the follow-up period, PEDs enlarged in eight eyes (40%) and were unchanged in two eyes (10%). Spontaneous resolution of the central PED(s) with AVLs was seen in four (20%) eyes. Rupture of the PED(s) occurred in four eyes (20%), with two developing central foveolar atrophy afterwards. Overall, central foveolar atrophy was seen ultimately in four eyes (20%).

Conclusion: It seems that high PED size may be a risk factor for PED rupture during follow-up. 1/3 of the eyes ended up with unfavorable anatomical outcome.


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