This site is intended for healthcare professionals
Journals
  • Home
  • /
  • Journals
  • /
  • Allergic reactions
  • /
  • Real-life experience on effectiveness and safety o...
Journal

Real-life experience on effectiveness and safety of dupilumab in adult patients with moderate-to-severe atopic dermatitis

Read time: 1 mins
Published:23rd Oct 2019
Author: Fargnoli MC, Esposito M, Ferrucci S, Girolomoni G, Offidani A, Patrizi A et al.
Availability: Pay for access, or by subscription
Ref.:J Dermatolog Treat. 2019:1-20.
DOI:10.1080/09546634.2019.1682503
Real-life experience on effectiveness and safety of dupilumab in adult patients with moderate-to-severe atopic dermatitis


Background:
Dupilumab, a fully human monoclonal antibody targeting the alpha subunit of IL-4 was recently approved for the treatment of moderate-to-severe atopic dermatitis (AD) in adult patients.

Objective: To assess dupilumab effectiveness and safety in adults with moderate-to-severe AD in a real-life Italian multicentre retrospective cohort.

Methods: Adult moderate-to-severe AD patients, referring to 39 Italian centers, received dupilumab in the context of a national patient access program. Disease assessment was performed at baseline, after 4 and 16 weeks of treatment using Eczema-Area-and-Severity-Index (EASI) score, itch and sleep numerical-rating-score (itch-NRS, sleep-NRS) and Dermatology-Life-Quality-Index (DLQI).

Results: A total of 109 (71 M/38F) patients was studied. There was a significant reduction in EASI score, itch-NRS, sleep-NRS and DLQI from baseline to week 4 and a further significant decline to week 16. EASI 50, EASI75 and EASI90 were achieved by 59.6%, 28.4% and 9.3% of patients at 4 weeks and by 87.2%, 60.6% and 32.4% of them at 16 weeks, respectively. Adverse events were experienced by 19.2% (21/109) of the patients and they were all mild in intensity, being conjunctivitis the most common side effect.

Conclusions: Dupilumab significantly improved disease severity, pruritus, sleep loss and quality of life with an acceptable safety profile.


Read abstract on library site  Access full article