Diagnosis of CS is usually prompted by clinical suspicion in patients with multiple and progressive signs and symptoms.
Screening is also often considered in patients with other features of CS, for example poorly controlled diabetes, hypertension, or unexplained osteoporosis. Patients with an incidentally discovered adrenal mass should be evaluated (Newell-Price et al., 2006; Sharma et al., 2015).
Once the diagnosis of CS has been confirmed, a combination of blood tests and MRI/CT scans can be employed to determine the cause of the CS (Newell-Price et al., 2006; Sharma et al., 2015).
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