Prevalence and incidence of atopic dermatitis
Atopic dermatitis, or atopic eczema, is the most common chronic skin condition and is characterised by acute episodes of eczematous, pruritic lesions over dry skin.
Atopic dermatitis, also called atopic eczema or eczema, is an inflammatory, chronic or chronically relapsing skin disease with pruritus as the predominant dermatological symptom36,59,83.
The condition typically presents in infancy, with 60% of cases occurring within the first year, however, it can develop in older patients with approximately one third of adult cases developing in adulthood36,83. Over time, the clinical presentation of atopic dermatitis changes36.
Burden of atopic dermatitis
As a chronic, relapsing skin condition, atopic dermatitis has a significant impact on patients’ quality of life.
Pathophysiology of atopic dermatitis
A complex range of factors influence the development and onset of atopic dermatitis, but what is the underlying mechanism that drives skin barrier dysfunction and inflammation? Discover how breakdown of the skin barrier can lead to allergen penetration and immune system activation.
In the past, atopic dermatitis was thought to be primarily a consequence of immune dysfunction in susceptible children. However, recent advances point towards a complex pathophysiology with genetic, barrier function, immunity and environmental factors acting together and synergistically to drive barrier dysfunction, inflammation and disease progression25.
Diagnosing atopic dermatitis
Diagnosis of atopic dermatitis relies strongly on clinical presentation and is typically made through an extensive history and physical examination2.
1. Nutten S. Atopic dermatitis: Global epidemiology and risk factors. Ann Nutr Metab. 2015;66:8–16.
2. Avena-Woods C. Overview of atopic dermatitis. Am J Manag Care. 2017;23(8):S115–S123.
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