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Areas covered: Encorafenib in combination with bimetinib offers a new approach that may offer benefits over existing BRAF/MEK inhibitor combinations.

The introduction of BRAF and MEK inhibitors into clinical practice improved the prognosis of metastatic melanoma patients. The combination of BRAF inhibitor dabrafenib with MEK inhibitor trametinib has shown...

We sought to determine whether adjuvant dabrafenib plus trametinib would improve outcomes in patients with resected, stage III melanoma with BRAF V600 mutations.

Background: Combined BRAF-MEK inhibitor therapy is the standard of care for BRAFV600-mutant advanced melanoma.

Major advances in the understanding of the pathophysiology of melanoma have led to a new era of melanoma treatment with targeted therapy and immunotherapies. Since 2011, four new classes of medications...

Background: Dual inhibition of the mitogen-activated protein kinase pathway with BRAF/MEK inhibitor (BRAFi/MEKi) therapy is a standard treatment for BRAFV600-mutant metastatic melanoma and has historically been associated with grade III pyrexia or photosensitivity depending on the combination used.

This European guideline update details treatment strategies for cutaneous melanoma, including surgical margins, sentinel lymph node biopsy, and systemic therapies. It covers adjuvant and neoadjuvant immunotherapy, targeted therapy for BRAFV600 mutations, and recommendations for advanced disease management.

The SEOM-GEM guidelines address the rising incidence of cutaneous melanoma and emphasize early diagnosis and timely treatment. They provide evidence-based recommendations for adjuvant and neoadjuvant therapies, advanced disease management, and follow-up strategies, including special cases like brain metastases.

This ASCO guideline update reviews systemic therapy for melanoma, adding new recommendations for neoadjuvant pembrolizumab, adjuvant nivolumab or pembrolizumab, and combination regimens for advanced disease. It also removes outdated options like talimogene laherparepvec.

Historically, the median overall survival of metastatic melanoma patients was less than 1 year and long-term survivors were rare. Recent advances in therapies have dramatically shifted this landscape...