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    10/09/19

    Role of microRNAs in chronic lymphocytic leukemia pathogenesis.

    MicroRNAs (miRNAs) are a group of small endogenous non-coding RNAs involved in many cancers and various cellular processes such as cellular growth, DNA methylation, apoptosis, and differentiation.

    • Source: Current Medicinal Chemistry
    Journals
    Journal
    30/04/19

    Venetoclax in the treatment of chronic lymphocytic leukemia

    Areas covered: This article reviews the chemical structure, mechanisms of action, pharmacokinetic, and the clinical applications of venetoclax in monotherapy and in combined treatment of CLL.

    • Source: Expert Opinion on Drug Metabolism & Toxicology
    Journals
    Journal
    01/11/19

    Chronic lymphocytic leukaemia: from genetics to treatment.

    Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature CD5+CD23+ B cells in the peripheral blood...

    • Source: Nature Reviews Clinical Oncology
    Journals
    Journal
    01/03/19

    Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia

    Objective/Background: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate...

    • Source: Hematology/Oncology and Stem Cell Therapy
    Journals
    Journal
    01/02/19

    Brain invasion by chronic lymphocytic leukemia

    Brain invasion by chronic lymphocytic leukemia (CLL) is very rare, and only a handful of cases have been reported. We here report a case of 61-year-old woman who had been treated for CLL for 14 years presenting with a progressive...

    • Source: Neuropathology
    Journals
    Journal
    24/04/19

    Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables

    To define the efficacy of venetoclax with extended follow-up and identify clinical or biological treatment-effect modifiers, updated data for previously treated patients with chronic lymphocytic leukemia (CLL) or small lymphocytic...

    • Source: Blood
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    Drug news
    22/11/19

    FDA approves Calquence to treat chronic lymphocytic leukaemia or small lymphocytic lymphoma.- AstraZeneca.

    AstraZeneca announced that the FDA has approved Calquence (acalabrutinib) for adult patients with chronic lymphocytic leukaemia (CLL) or small lymphocytic...

    Journals
    Journal
    01/01/18

    Experience with ibrutinib for first-line use in patients with chronic lymphocytic leukemia

    Ibrutinib is the first in-class, orally administered, Bruton's tyrosine kinase (BTK) inhibitor that abrogates the critical signaling downstream of the B-cell receptor (BCR).

    • Source: Therapeutic Advances in Hematology
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    Drug news
    20/06/22

    NICE (UK)recommends venetoclax for treatment of chronic lymphocytic leukemia.

    The National Institute for Health and Care Excellence (NICE)(UK); Venetoclax monotherapy is recommended, within its marketing authorisation, for treating chronic lymphocytic leukaemia (CLL) in adults

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    Drug news
    09/03/16

    FDA approves Imbruvica (ibrutinib) as a first-line treatment for patients with chronic lymphocytic leukaemia (CLL)- AbbVie + Janssen Biotech

    AbbVie announced that the FDA has approved Imbruvica (ibrutinib) as a first-line treatment for patients with chronic lymphocytic leukaemia (CLL)....

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