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The clinical course of heart failure is characterised by progressive worsening of cardiac function and symptoms. Patients progress to a condition where traditional treatment is no longer effective and advanced therapies...

Aims: The LION-HEART study was a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial evaluating the efficacy and safety of intravenous administration of intermittent doses of levosimendan in outpatients with advanced chronic heart failure.

End-stage heart failure (HF) frequently needs continuous inotropic support in hospital and has high morbidity and mortality in absence of heart transplantation.

The longer survival of patients with Duchenne muscular dystrophy due to advances in clinical care has increased the incidence of Duchenne muscular dystrophy-associated cardiomyopathy, a nearly consistent feature in the third decade...

Aims: Levosimendan improves haemodynamics in acute decompensated heart failure (HF). However, it is increasingly used for repetitive or intermittent infusions in advanced but stable chronic HF, without clear indication...

The role of intermittent inotropes in AAHF is unclear. The RELEVANT-HF registry was designed to obtain insight on the effectiveness and safety of compassionate scheduled repetitive 24-hour levosimendan infusions (LEVO) in AAHF patients.

Discover the latest advancements in heart failure management with the 2022 AHA/ACC/HFSA Guideline. This comprehensive update offers patient-centric, evidence-based recommendations to enhance diagnosis, treatment, and overall care for heart failure patients, reflecting the most current research and clinical practices.

Abbott announced new late-breaking data that show its HeartMate 3 heart pump extends survival of advanced heart failure patients by at least five years, providing a clear life-saving option for people battling later stage disease.

Pulmonary hypertension is a multifactorial disease with a high morbidity and mortality.

Acute decompensated heart failure (ADHF) is associated with high morbidity and mortality.