An immunotherapy produced complete responses in 75% of patients with high-risk bladder cancer that had recurred despite standard treatment. Separately, a sweat-sensing fingertip patch tracked levodopa levels in Parkinson's disease as accurately as laboratory blood tests.
The FDA approved a self-administered furosemide autoinjector for treating fluid overload at home in patients with heart failure or kidney disease. In separate findings, an experimental blood test differentiated active tuberculosis from latent infection, exposure and uninfected status.
An experimental combination of zabopegdutide and TLY012 improved liver fat and liver damage measures in patients with biopsy-proven fatty liver disease. In separate findings, researchers reported that pigment-producing cells in vitiligo patches may enter a reversible dormant state.
New cardiovascular prevention guidelines recommend longer-term risk assessment and lower LDL cholesterol targets, with one study estimating statins could be recommended to 21.5 million additional U.S. adults. Separately, a California study reported a sharp rise in e-bike collisions and more moderate-to-severe injuries among e-bike riders than traditional cyclists.
A small Italian study found micro- and nano-plastics were detected more often in heart attack survivors than in patients with chronic ischemic heart disease or normal coronary arteries. In separate findings, an experimental KRAS-targeting vaccine generated durable immune responses in high-risk pancreatic cancer patients in a pilot trial.
Researchers developed a 3D-printing approach for customized rigid contact lenses using a new silicone formulation and surface-smoothing process. In separate findings, researchers reported that an emerging tick-borne nairovirus may possess immune-evasion mechanisms seen in related human pathogens.
In a study of patients with terminal lung cancer confined to the lungs, lung transplantation was associated with higher one-year survival than medical management alone. In separate findings, researchers reported sex differences in cancer stage at diagnosis and identified differences between human and mouse red blood cell production.
A randomized trial found dual-mobility hip implants were associated with lower dislocation rates than standard implants after hip replacement surgery for fracture patients. In separate findings, researchers described a revised mechanism of malaria parasite invasion of red blood cells and reported no increased adverse-event risk with same-day influenza and COVID vaccination.
In a pilot study of women with autoimmune premature ovarian insufficiency, rituximab treatment was associated with follicle development and healthy births in some patients. Separately, researchers reported that more than 98% of statin-eligible individuals were at low risk of serious muscle disorders, while mouse studies explored mechanisms underlying statin myopathies.
