Patients report gaps in care and support
A study of nearly 28,000 GLP-1 drug users found genetic variants associated with differences in weight-loss response and risks of nausea or vomiting. In separate findings, researchers examined cardiovascular effects of semaglutide and reported sex reversal in mice after a single non-coding DNA mutation.
A study of active military personnel and veterans found MRI-guided, robot-controlled transcranial magnetic stimulation combined with psychotherapy was associated with greater PTSD symptom reductions than psychotherapy alone. In separate findings, researchers reported sex-related differences in patterns of brain shrinkage and cognitive assessment results in Alzheimer's disease.
A study found selected patients over age 80 who underwent surgery for early-stage lung cancer had five-year survival rates comparable to younger patients. In separate findings, U.S. poison control data showed a sharp increase in kratom-related exposures and hospitalizations between 2015 and 2025.
In mice with fatty liver disease, semaglutide acted on a subset of liver cells and was associated with reduced liver inflammation independent of weight loss. In separate findings, researchers identified defects in antibody-producing immune structures that may help explain reduced vaccine responses in obesity.
Researchers reported a modified CRISPR approach improved insertion of the XIST gene into an extra chromosome 21 in laboratory studies related to Down syndrome. In separate findings, gene-edited stem cells produced long-lasting broadly neutralizing antibodies against HIV, influenza and malaria in mice.
A study found genomic testing identified high-risk breast cancer tumors that may be missed by standard clinical biomarkers and reported similar outcomes across racial groups when appropriate care was provided. In separate findings, researchers reported that some heart attack survivors could discontinue beta-blockers after one year and that fluvoxamine improved fatigue in adults with long COVID.
A mid-stage trial found elraglusib plus chemotherapy was associated with longer survival than chemotherapy alone in advanced pancreatic cancer. In separate findings, researchers compared AI-generated and clinician-written clinical notes and reported associations between wildfire smoke exposure and several cancer types.
Interim trial results found duodenal mucosal resurfacing was associated with less weight regain after discontinuation of tirzepatide. In separate findings, researchers compared approaches for replacing failed mitral valves and tested a low-plastic diet intervention.
A trial found pulsed-field catheter ablation was associated with higher rates of freedom from abnormal heart rhythms than drug therapy in patients with persistent atrial fibrillation. In separate findings, researchers evaluated blood filtering for preeclampsia and an immune-cell priming approach to reduce immunosuppression after liver transplantation.
