A pooled analysis of nine studies found shingles vaccination was associated with lower risks of heart attack and stroke in adults. In separate findings, partial heart transplantation using donor valves showed functioning grafts and valve growth in children with congenital heart valve defects.
An early-stage trial found Jasper Therapeutics' briquilimab enabled stem cell transplantation in children with Fanconi anemia without chemotherapy or radiation conditioning. Elsewhere, a screening program improved osteoporosis testing in at-risk older men, while Merck's monthly oral HIV PrEP candidate advanced in human testing.
A study of more than 86,000 matched patients found GLP-1 drug use was associated with lower overall risk of several obesity-related cancers. In separate findings, researchers developed a protein-coating technology for injectable biologics and tested weight-loss microbeads in rats.
Researchers developed human fetal kidney organoids that can grow for six to eight months in laboratory conditions, enabling observation of kidney development over periods resembling pregnancy. In separate findings, researchers identified an IL-23-mediated mechanism that may limit therapeutic HPV vaccine effectiveness, while early hearing aid use was associated with a lower risk of dementia.
An experimental blood test identified ovarian cancer with 92% accuracy overall and 88% accuracy for stage I and II disease in women with possible symptoms. Separately, researchers examined mechanisms behind age-related blood-brain barrier leakage and reported that wildfire smoke-related mortality in Europe may be higher than previously estimated.
A review of 12 randomized trials found weight-loss interventions may increase the likelihood of spontaneous pregnancy in women seeking IVF, although effects on IVF success and live births were unclear. In separate findings, researchers developed magnetic nanobots that sealed exposed tooth tubules and reduced tooth sensitivity in laboratory and animal studies.
A Swedish study identified DNA methylation patterns associated with future cardiovascular complications in people with newly diagnosed type 2 diabetes. In separate findings, researchers identified a maple syrup compound that inhibited cavity-causing bacteria and biofilm formation.
In laboratory and animal studies, a drug combination containing theobromine and arainosine showed greater activity against influenza viruses than oseltamivir, including bird flu and swine flu strains. Separately, U.S. studies linked expanded colorectal cancer screening among adults ages 45 to 49 with increased detection of early-stage colorectal cancers.
Qualitative evidence shows barriers to prostate cancer diagnosis in Black men, but tailored interventions can facilitate improved outcomes.
Review indicates that rising ctDNA levels are a strong prognostic marker for disease progression and cancer-related mortality.
A RAISE sub-analysis shows that zilucoplan improves outcomes in patients with gMG without prior immunoglobulin or plasma exchange.
Findings from the RAAINBOW study indicate that the novel topical agent cinainu is efficacious for children and adolescents with alopecia areata.
