A study found supplemental (Z)-endoxifen achieved target drug concentrations in breast cancer patients with impaired tamoxifen metabolism. In separate findings, researchers developed a magnetic capsule system that deposited bio-ink in the stomachs of rabbits.
Researchers reported successful transplantation of an enzyme-converted blood type A kidney functioning as a type O kidney in a first-in-human experiment. In separate findings, a gene therapy improved kidney function in diabetic mice, while a study found prolonged preoperative fluid restriction in U.S. children.
Two studies found harmful genetic mutations in sperm increased with paternal age and identified genes in which mutations may gain a selective advantage during sperm production. In separate findings, a review questioned the benefit-risk profile of tramadol for chronic pain, while a Scottish study found at-home medical abortion before 12 weeks had success rates comparable to hospital-based care.
A large genetic study found substantially more depression-associated DNA variants in females than in males and linked female depression risk with metabolic traits. In separate findings, researchers reported microbiome changes associated with microplastic exposure and linked both sugar-sweetened and artificially sweetened beverages with fatty liver disease risk.
Two late-stage trials found the experimental cannabis-derived drug VER-01 improved chronic lower back pain, sleep quality and physical function. In separate findings, a high-cysteine diet promoted intestinal tissue regeneration and reduced injury in mouse studies.
Studies presented at ASTRO found low-dose radiotherapy improved pain and function in patients with osteoarthritis and was associated with a low risk of treatment-related malignancies. In separate findings, researchers evaluated radiotherapy for recurrent ventricular tachycardia and intranasal epinephrine as a potential alternative to injections for anaphylaxis.
Cross-sectional, observational study reveals that diagnostic delays and misdiagnoses remain common across CIDP variants
The latest from FLAURA2 and NorthStar presented at ESMO 2025 offers guidance on the use of osimertinib in EGFR-mutated NSCLC.
Alectinib treatment results in large survival gains versus crizotinib in advanced ALK-positive NSCLC, report the ALEX investigators at ESMO 2025.
GDFATHER-NEO: Adding the GDF-15 inhibitor visugromab to nivolumab improves outcomes for patients with MIBC unfit for neoadjuvant chemotherapy.
Final survival analysis of the BladderPath trial supports use of MRI-based staging for patients with suspected muscle-invasive bladder cancer.
HARMONi-6 data show ivonescimab plus chemotherapy improves PFS in advanced squamous non–small-cell lung cancer, as seen at ESMO 2025.
Combining disitamab vedotin with toripalimab is superior to platinum-based chemotherapy in HER2-positive advanced urothelial carcinoma.
Results of OptiTROP-Lung04 show increased survival with sacituzumab tirumotecan in EGFR-mutated non–small-cell lung cancer (NSCLC) at ESMO 2025.
A study found mRNA COVID vaccination within 100 days of starting immunotherapy was associated with longer survival in patients with advanced non-small cell lung cancer and metastatic melanoma. Elsewhere, an experimental retinal implant restored central vision in patients with age-related macular degeneration in an early-stage study.
Studies presented at ESMO found antibody-drug conjugates improved progression-free or overall survival in several breast cancer settings. In related developments, circulating tumor DNA blood tests helped guide chemotherapy or immunotherapy decisions in colon and bladder cancer.
A study found the proportion of patients under age 50 hospitalized with complicated diverticulitis increased between 2005 and 2020. In separate findings, seven-year outcomes after Edwards' Sapien 3 transcatheter aortic valve replacement were similar to those after open-heart surgery in lower-risk patients.
A mid-stage trial found a bacteriophage cocktail plus antibiotics was associated with higher response rates than antibiotics alone in patients with Staphylococcus aureus bloodstream infections. Elsewhere, researchers developed decoy molecules targeting yellow fever and tick-borne viruses and identified a mechanism that helps Pseudomonas aeruginosa form antibiotic-resistant biofilms.
