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Adcetris combination significantly improves overall survival in newly diagnosed patients with advanced Hodgkin lymphoma.

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Published:4th Feb 2022
Seagen Inc. announced that the phase III ECHELON-1 clinical trial demonstrated a statistically significant improvement in overall survival (OS) (p=0.009) in patients with advanced classical Hodgkin lymphoma (cHL) following treatment with Adcetris (brentuximab vedotin) in combination with chemotherapy.

With approximately six years median follow up, patients receiving Adcetris plus doxorubicin, vinblastine, and dacarbazine (A+AVD) in the frontline setting had a 41 percent reduction in the risk of death (HR 0.59; [95% CI: 0.396 to 0.879]) compared with patients receiving doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD). The safety profile of Adcetris was consistent with previous studies and no new safety signals were observed.

ECHELON-1 is an open-label, international, randomized, phase III trial evaluating the safety and efficacy of frontline Adcetris plus AVD versus ABVD in 1,334 adult patients with stage III or IV cHL. Patients were randomly assigned to receive A+AVD or ABVD intravenously on days 1 and 15 of each 28-day cycle for up to six cycles. OS is the key secondary endpoint of the trial. The primary endpoint, modified progression free survival, served as the basis for global regulatory approvals.

Adcetris is approved for certain types of relapsed or refractory Hodgkin lymphoma (HL) including previously untreated Stage III/IV cHL and previously untreated peripheral T-cell lymphoma (PTCL). It has received marketing authorization in more than 75 countries and is being evaluated globally in more than 70 corporate- and investigator-sponsored clinical trials across multiple settings in lymphoma and other diseases.

Condition: Hodgkin Lymphoma
Type: drug

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