Travere Therapeutics announces successful outcome from Type A meeting with FDA

“We are very pleased with the outcome of the Type A meeting which confirms our plan to provide FDA with additional eGFR data from the ongoing DUPLEX Study in the first half of 2022 to continue on the accelerated approval pathway for sparsentan in FSGS,” said Eric Dube, Ph.D., chief executive officer of Travere Therapeutics. “If the additional data further strengthen the prediction of long-term benefit in the study as we expect, we anticipate submitting a New Drug Application for accelerated approval of sparsentan for FSGS in the middle of next year and furthering our preparations to deliver it as a potential new treatment standard for FSGS, if approved.”

Following the outcome of the Type A meeting, the Company intends to continue with its plan to provide the FDA with additional eGFR data from the ongoing DUPLEX Study in the first half of 2022. At the time of the eGFR data cut, all patients remaining in the DUPLEX Study will have completed one year of treatment, and approximately 50 percent of patients will have completed two years of treatment.

The Company plans to submit an application for accelerated approval in the U.S. in mid-2022, pending additional supportive eGFR data. The DUPLEX Study is continuing as planned with no changes to the statistical analysis plan, and patients will proceed in a blinded manner to assess the treatment effect on eGFR slope over 108 weeks in the confirmatory endpoint analysis.