RECOVERY trial shows no benefit from hydroxycholoroquine as treatmant for COVID-19.- Novartis

In March 2020 RECOVERY was established as a randomised clinical trial to test a range of potential drugs for COVID-19, including hydroxycholoroquine. The trial has proceeded at unprecedented speed, enrolling over 11,000 patients from 175 NHS hospitals in the UK. Throughout this time, the independent Data Monitoring Committee has reviewed the emerging data about every two weeks to determine if there is evidence that would be strong enough to affect national and global treatment of COVID-19. On Thursday 4 June, in response to a request from the UK Medicines and Healthcare Products Regulatory Agency (MHRA), the independent Data Monitoring Committee conducted a further review of the data. The Committee recommended the chief investigators review the unblinded data on the hydroxychloroquine arm of the trial. The authors have concluded that there is no beneficial effect of hydroxychloroquine in patients hospitalised with COVID-19. They have therefore decided to stop enrolling participants to the hydroxychloroquine arm of the RECOVERY Trial with immediate effect. The authors are now releasing the preliminary results as they have important implications for patient care and public health. A total of 1542 patients were randomised to hydroxychloroquine and compared with 3132 patients randomised to usual care alone. There was no significant difference in the primary endpoint of 28-day mortality (25.7% hydroxychloroquine vs. 23.5% usual care; hazard ratio 1.11 [95% confidence interval 0.98-1.26]; p=0.10). There was also no evidence of beneficial effects on hospital stay duration or other outcomes. These data convincingly rule out any meaningful mortality benefit of hydroxychloroquine in patients hospitalised with COVID-19. Full results will be made available as soon as possible. "These data convincingly rule out any meaningful mortality benefit of hydroxychloroquine in patients hospitalized with COVID-19," said study investigators Peter Horby and Martin Landray, both of whom are professors at the University of Oxford, which led the trial. .