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Update on phase III GY004 trial for cediranib + Lynparza in platinum-sensitive relapsed ovarian cancer.- AstraZeneca + Merck Inc.

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Published:13th Mar 2020
AstraZeneca and Merck Inc.,announced high-level results from the Phase III GY004 trial led by NRG Oncology and sponsored by the US National Cancer Institute (NCI), that examined primarily the efficacy and safety of the potential new medicine cediranib added to Lynparza (olaparib) versus platinum-based chemotherapy in patients with platinum-sensitive relapsed ovarian cancer. Ovarian cancer is the eighth most common cause of death from cancer in women worldwide. The trial did not meet the primary endpoint in the intent-to-treat (ITT) population of a statistically significant improvement in progression-free survival (PFS) with cediranib added to Lynparza versus platinum-based chemotherapy. Cediranib is an oral vascular endothelial growth factor receptor (VEGFR) inhibitor, which blocks the growth of blood vessels supporting tumour growth.
Condition: Ovarian Cancer
Type: drug

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