Phase II registrational trial of Enhertu to treat HER2-positive unresectable or metastatic gastric or gastroesophageal junction cancer . AstraZeneca + Daiichi Sankyo
Related news and insights
AstraZeneca and Daiichi Sankyo have announced that the FDA has approved label expansion for Enhertu (fam-trastuzumab deruxtecan-nxki) to include adults with locally advanced or metastatic HER2-positive gastric or gastroesophageal (GEJ) adenocarcinoma that would have previously been treated with a trastuzumab-based regimen.
Bristol Myers Squibb announced that CheckMate -649, a pivotal Phase III trial evaluating Opdivo (nivolumab) plus chemotherapy compared to chemotherapy alone as a first-line treatment for metastatic gastric cancer, gastroesophageal junction (GEJ) cancer or esophageal adenocarcinoma
Detailed results from the positive, registrational, randomised controlled Phase II DESTINY-Gastric01 trial showed AstraZeneca and Daiichi Sankyo Company, Limited (Daiichi Sankyo)’s Enhertu (trastuzumab deruxtecan) demonstrated a statistically significant and clinically meaningful improvement in objective response rate (ORR) and overall survival (OS) , a key secondary endpoint, versus chemotherapy.