Eli Lilly announces the launch of TRIUMPH, long-term, real-world evidence study of Emgality in migraine.

Eli Lilly and Company announced the launch of TRIUMPH, a long-term, real-world evidence study of Emgality (galcanezumab-gnlm). The objective of the TRIUMPH study (Preventive Treatment of Migraine: Outcomes for Patients in Real-World Healthcare Systems) is to evaluate the real-world effectiveness of Emgality, in comparison to other preventive treatments for migraine, among people receiving routine medical care who are switching or beginning a new prescription treatment for migraine prevention.

The TRIUMPH study has a planned enrollment of approximately 2,850 patients from multiple sites across the U.S., Europe and Asia. The study will track prescribing and treatment choices related to migraine preventive treatment use over a two-year period and will include comparison of switching patterns and discontinuation rates between Emgality, other approved CGRP antibodies, oral migraine preventive treatments and botulinum toxin A or B. Patient-reported outcomes related to migraine burden, quality of life and overall-treatment satisfaction will be assessed. The study will also examine reduction in monthly migraine headache days, acute medication outcomes and other patterns of migraine treatment use over the two-year period. Throughout the study, treatment initiation or changes are solely at the discretion of the physician investigator and the patient.

For over 25 years, Lilly has been committed to helping people affected by disabling headache disorders, investigating more than a dozen different compounds. Lilly is also conducting ongoing observational studies to expand the breadth and depth of knowledge in the field of migraine. These studies include TRIUMPH, as well as OVERCOME. The OVERCOME study aims to be the largest U.S. study of its kind and is intended to further understanding of the burden and stigma experienced by people living with migraine, to identify barriers to appropriate treatment of migraine and to assess how the introduction of novel preventive and acute treatment options may influence delivery of migraine care.