Bristol-Myers Squibb-Pfizer Alliance will present 15 Eliquis posters at the ESC Congress 2018 and new analyses from the ACROPOLIS (Apixaban ExperienCe Through Real-WOrld POpuLatIon Studies) study.

The Bristol-Myers Squibb-Pfizer Alliance will present 15 Eliquis (apixaban) posters at the ESC Congress 2018 held in Munich, Germany, August 25-29, 2018. Nine of the posters to be presented are new analyses from the global real-world data (RWD) program, ACROPOLIS (Apixaban ExperienCe Through Real-WOrld POpuLatIon Studies), exploring the effectiveness and safety of anticoagulants, including Eliquis, among patients with non-valvular atrial fibrillation. These data add to the growing body of real-world evidence for Eliquis, which now includes a sample size of more than 970,000 lives. The analyses that will be presented at the ESC Congress 2018 as part of ACROPOLIS will offer new insights on patients who have non-valvular atrial fibrillation and a range of comorbidities. The analyses explore other important topics such as healthcare costs, including hospitalization due to bleeding. The ACROPOLIS program provides a robust source of complementary information to healthcare professionals. The source and type of RWD may limit how results and endpoints can be applied to the overall patient population. RWD should not be used as stand-alone evidence for healthcare decision making.

Limitations of Real-World Data Analyses: Real-world data have the potential to complement randomized controlled trial data by providing additional information about how a medicine performs in routine medical practice. Real-world data analyses have several limitations. For example, the source and type of data used may limit the generalizability of the results and of the endpoints. Observational real-world studies can only evaluate association and not causality. Due to these limitations, real-world data analyses are not used as stand-alone evidence to validate the efficacy and/or safety of a treatment. It is important to note that, at this time, there are no head-to-head clinical trials comparing direct oral anticoagulants.

BMS-Pfizer Alliance Real-Word Data (RWD) Program: The Bristol-Myers Squibb-Pfizer Alliance global RWD analysis program, ACROPOLIS (Apixaban ExperienCe Through Real-WOrld POpuLatIon Studies) is designed to generate additional evidence from routine clinical practice settings to further inform healthcare decision makers, including healthcare providers and payers. The ACROPOLIS program includes retrospective, outcomes-based analyses of patients from 19 databases around the world, including anonymized medical records, medical and pharmacy health insurance claims data, and national health data systems. To date, the ACROPOLIS program includes a sample size of more than 970,000 lives spanning 11 countries. Analyses of real-world data allow for a broader understanding of patient outcomes associated with Eliquis outside of the clinical trial setting, as well as insight into other measures of healthcare delivery, such as hospitalization and costs.