Results of LATITUDE study of filtering for Emblem S-ICD System in ventricular arrhythmias published in Heart Rhythm Journal.- Boston Scientific.

Boston Scientific announced results from an analysis of the LATITUDE database which evaluated the successful reduction of inappropriate shocks using the SMART Pass sensing filter in patients implanted with the Emblem Subcutaneous Implantable Defibrillator (S-ICD) System. The real-world data demonstrated that when the sensing filter was in use, the rate of inappropriate shocks was reduced to 4.3% at one year. The analysis was also published online in the Heart Rhythm Journal.

The SMART Pass sensing filter is an advanced algorithm within the Emblem S-ICD System that filters out certain signals that are the primary reason for inappropriate shocks, while maintaining the ability to accurately detect ventricular tachycardia or ventricular fibrillation and deliver lifesaving therapy. Study authors evaluated the effect of SMART Pass on shocks in ambulatory patients and found that the filter reduced the risk for the first inappropriate shock by 50% and the risk for all inappropriate shocks by 68%, without a negative impact on delivery of appropriate shocks.

The prospective, blinded evaluation reviewed one year of remote monitoring data from 1,984 patients that were implanted with an Emblem S-ICD System between 2015 and 2016. The data were presented during a late-breaking clinical trial at Heart Rhythm 2018, the Heart Rhythm Society's 39th Annual Scientific Sessions.

See: "A Prospective, Blinded Evaluation Of A Novel Sensing Methodology Designed To Reduce Inappropriate Shocks By The Subcutaneous Implantable Defibrillator" Dominic A.M.J. Theuns et al. Heart Rhythm Journal, May 11, 2018 DOI: https://doi.org/10.1016/j.hrthm.2018.05.011