Takeda makes fourth proposal for takeover of Shire plc

Shire notes the announcement made by Takeda and confirms it has received a fourth proposal on 20 April 2018 regarding a possible offer for the Company (the �Fourth Proposal�). The Fourth Proposal comprises �26 per share in new Takeda shares, to be listed in Japan and in the US through an ADR listing, and �21 per share in cash, representing a potential value of �47 per share and approximately �44 billion for the total issued and to be issued share capital of the Company. Based on Takeda's current market capitalisation, Shire shareholders would own approximately 49 per cent. of the enlarged Takeda. The Board of Shire is considering its position with respect to the Fourth Proposal and will issue a further announcement in due course.