Trial analysis presented at the American Heart Association (AHA) shows Lixiana has greater reductions in ischaemic events compared to warfarin

Daiichi Sankyo Company, Limited announced results of a sub-analysis from its global phase III ENGAGE AF-TIMI 48 trial that evaluated the safety and efficacy profile of edoxaban (the brand name LIXIANA) in patients with AF. It included a post-hoc analysis from the ENGAGE AF-TIMI 48 trial, providing insights on edoxaban in AF patients with established CAD, and found those on an edoxaban regimen (60/30 mg) versus warfarin had greater reductions in ischaemic events, compared to those without CAD. The data was presented at the American Heart Association (AHA) Scientific Sessions on 11 – 15 November in Anaheim, California.

In the sub-analysis, findings showed that among AF patients with known CAD, those treated with edoxaban compared to warfarin, had greater reductions in stroke/systemic embolic events (SEE) (1.4 versus 2.1%) and myocardial infarction (MI) (1.4 versus 2.0%), compared to patients without CAD [stroke/SEE in edoxaban vs warfarin (1.6 versus 1.7%); MI in edoxaban vs warfarin (0.5 versus 0.4%)]. Major bleeding rates in patients who received edoxaban were significantly lower than in patients who received warfarin, regardless of CAD status [CAD patients on edoxaban versus warfarin (3.6 versus 4.4%); patients without CAD on edoxaban versus warfarin (2.5 versus 3.2%)].The ENGAGE AF-TIMI 48 trial was designed to study the safety and efficacy of edoxaban compared to warfarin in patients with AF (n=21,105) and moderate to high risk for stroke (CHADS2?2) or stroke/systemic embolic events.