Study of Chemosat (melphalan for injection) shows survival benefit in metastatic uveal melanoma patients- Delcath Systems

Delcath Systems has announced that data from a large single hospital experience of Chemosat (melphalan for injection) conducted at Southampton University Hospital in the United Kingdom were presented at the 6th European Post-Chicago Melanoma/Skin Cancer Meeting. Researchers conducted a retrospective evaluation of 27 metastatic uveal melanoma patients treated with CHEMOSAT over four years, analyzing survival, tumor response, time to progression and treatment related adverse events. Two patients could not be treated and were excluded from analysis; 25 patients received 43 treatments. Results showed that 14 patients remained alive after a median 290 days. Of 24 evaluable patients, one patient had a complete response (4%), five patients had partial responses (21%), and 12 patients had stable disease for greater than 90 days (50%).

Progression free survival for patients who had progressed was 181 days at the time of data cut off, and 11 patients were alive for greater than one year following their first treatment with a projected media overall survival of 511 days. Eleven deaths from disease progression occurred at a median of 264 days following first treatment, and there were no treatment related deaths. Treatment overall was well tolerated, and non-hematological adverse events (6) were relatively rare. Most common adverse events were transient, mild less than grade 2 and included transaminitis (64%) and thrombocytopenia (88%); grade 3 anemia was seen in 36% of patients and grade 3-4 neutropenia was seen in 6 patients.