Results from SURVEYOR studies for ABT 493 + ABT 530 fixed dose combination for non-cirrhotic patients with Hepatitis C- AbbVie

AbbVie has announced data from the SURVEYOR studies of its investigational HCV regimen, ABT-493, an NS3/4A protease inhibitor, and ABT-530, an NS5A inhibitor, that show high rates of sustained virologic response at 12 weeks post-treatment (SVR12) in non-cirrhotic patients with chronic hepatitis C virus (HCV) infection.

After 12 weeks of treatment, SVR 12 rates achieved were 97-100 percent in genotype 1 (GT1), 96-100 percent in genotype 2 (GT2) and 83-94 percent in genotype 3 (GT3) patients. These data were presented at The Liver Meeting 2015, the Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in San Francisco.

Separately, in a late-breaking presentation of the SURVEYOR-I study, data show non-cirrhotic GT1 chronic HCV patients who received a shorter duration of treatment for 8 weeks with ABT-493 and ABT-530 achieved a SVR12 rate of 97 percent.SURVEYOR-I and SURVEYOR-II are ongoing Phase II clinical studies that evaluate the safety and efficacy of ABT-493 and ABT-530, with or without ribavirin (RBV), for 8 to 12 weeks. These data presented at AASLD include non-cirrhotic patients with GT1, GT2 and GT3 chronic HCV infection. Data in additional patient populations (genotypes 4-6) will be presented at future meetings.

Comment: The test will be to achieve equivalent rates of SVR in patients with cirrhosis. AbbVie will treat genotype 2 and 3 patients with ABT-493 + ABT-530 for eight weeks in Phase III.