Tivozanib fails BATON trial for Colorectal Cancer- Aveo Oncology/Astellas

AVEO Oncology announced that data from a planned interim analysis of the Phase II BATON (Biomarker Assessment of Tivozanib in ONcology) study in patients with Colorectal Cancer indicate that the study is unlikely to meet the primary endpoint in the intent-to-treat patient population. BATON-CRC, led by Astellas, is an open-label, randomized Phase II study with a primary endpoint evaluating the superiority of tivozanib in combination with modified FOLFOX6, a standard chemotherapy, compared to bevacizumab in combination with modified FOLFOX6 as first-line treatment in patients with advanced metastatic Colorectal Cancer. A component of the BATON-CRC study is the assessment of biomarker relationships that may be predictive of response in select, pre-defined patient subpopulations. Data from the planned interim analysis, including biomarker data, are being analyzed.