Positive results for Carillon Mitral Contour System (Cardiac Dimensions) for Heart Surgery

New results of the TITAN trial of the Carillon Mitral Contour System, from Cardiac Dimensions, show that implanted patients demonstrated significant reductions in functional mitral regurgitation (FMR) as assessed by multiple quantitative measures, including regurgitant volume, which decreased from 34.5 to 17.4 ml through 12 months (p<0.001). additionally patients experienced significant reverse remodeling with left ventricular diastolic and systolic volumes decreasing through 12 months compared to progressive left ventricular dilation among the comparison group. there were also marked improvement in functional capacity among implanted patients through 24 months with six-minute walk distances increasing by 131.9 plus or minus 80 meters p><0.001). fifty-three patients were enrolled in titan with 36 patients implanted with the carillon device and 17 serving as a non-implanted comparison group. see: treatment of functional mitral regurgitation by percutaneous annuloplasty: results of the titan trial tomasz siminiak et al.eur j heart fail may 21 2012 doi: 10.1093 eurjhf hfs076>