Guideline for laboratory diagnosis and monitoring of von Willebrand disease: A joint guideline from the UKHCDO and the BSH

Guideline for laboratory diagnosis and monitoring of von Willebrand disease: A joint guideline from the United Kingdom Haemophilia Centre Doctors' Organisation (UKHCDO) and the British Society for Haematology (BSH)

This guideline updates the previous guidelines^{1, 2} published on behalf of the British Society for Haematology (BSH) and the United Kingdom Haemophilia Centre Doctors' Organisation (UKHCDO), focusing on the laboratory components of diagnosis and monitoring. Clinical aspects will be addressed in a separate guideline.

This guideline describes laboratory tests used to diagnose and monitor individuals with von Willebrand disease (VWD). Since the publication of the previous guideline,¹ new functional tests have become widely available as an alternative to the ristocetin cofactor assay. This guideline also updates genetic testing rationale and highlights the American College of Medical Genetics and Genomics (ACMG) guidelines for interpretation of sequence variants^{3, 4} and Association for Clinical Genomic Science (ACGS) guidelines for variant interpretation.⁵ 


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