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Read time: 13 mins
Last updated: 06 May 2020
Published: 24 Jul 2020

4.1 Therapeutic indications

Prevention of Rh(D) isoimmunisation in Rh(D) negative women

• Antepartum prophylaxis

- Planned antepartum prophylaxis

- Antepartum prophylaxis following complications of pregnancy including:

Abortion/threatened abortion, ectopic pregnancy or hydatidiform mole, intrauterine foetal death, transplacental haemorrhage resulting from antepartum haemorrhage, amniocentesis, chorionic biopsy, obstetric manipulative procedures e.g. external version, invasive interventions, cordocentesis, blunt abdominal trauma or foetal therapeutic intervention.

• Postpartum prophylaxis

- Delivery of a Rh(D) positive (D, Dweak, Dpartial) baby

An Rh(D) incompatible pregnancy is assumed if the foetus/baby is either Rh(D) positive or Rh(D) unknown or if the father is either Rh(D) positive or Rh(D) unknown.

Treatment of Rh(D) negative adults, children and adolescents (0 – 18 years) after incompatible transfusions of Rh(D) positive blood or other products containing red blood cells e.g. platelet concentrate.

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Drugs appearing in this section are approved by UK Medicines & Healthcare Products Regulatory Agency (MHRA), & the European Medicines Agency (EMA).