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Read time: 11 mins
Last updated: 06 May 2020
Published: 24 Jul 2020

4.1 Therapeutic indications

Prevention of Rh(D) immunisation in Rh(D) negative women of childbearing age

• Antenatal prophylaxis

Planned antenatal prophylaxis

Antenatal prophylaxis following complications of pregnancy including:

Abortion/threatened abortion, ectopic pregnancy or hydatidiform mole, intrauterine foetal death (IUFD), transplacental haemorrhage (TPH) resulting from ante-partum haemorrhage (APH), amniocentesis, chorionic biopsy, obstetric manipulative procedures e.g. external version, invasive interventions, cordocentesis, blunt abdominal trauma or foetal therapeutic intervention

• Post-natal prophylaxis

Delivery of a Rh(D) positive (D, Dweak, Dpartial) baby

Treatment of Rh(D) negative persons after incompatible transfusions of Rh(D) positive blood or other products containing red blood cells e.g. platelet concentrate.

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