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Daptomycin 350 mg powder for solution for injection/infusion

Read time: 36 mins
Last updated: 17 Sep 2020
Published: 17 Sep 2020

4.1 Therapeutic indications

Daptomycin is indicated for the treatment of the following infections (see sections 4.4 and 5.1).

- Adult and paediatric (2 to 17 years of age) patients with complicated skin and soft-tissue infections (cSSTI).

- Adult patients with right-sided infective endocarditis (RIE) due to Staphylococcus aureus. It is recommended that the decision to use daptomycin should take into account the antibacterial susceptibility of the organism and should be based on expert advice. See sections 4.4 and 5.1.

Adult and paediatric (1 to 17 years of age) patients with Staphylococcus aureus bacteraemia (SAB) In adults, use in bacteraemia should be associated with RIE or with cSSTI, while in paediatric patients, use in bacteraemia should be associated with cSSTI.

Daptomycin is active against Gram-positive bacteria only (see section 5.1). In mixed infections where Gram-negative and/or certain types of anaerobic bacteria are suspected, Daptomycin should be co-administered with appropriate antibacterial agent(s).

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

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