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Drug information

Octreotide 200 micrograms/ml solution for injection (multidose vial)

POM
Read time: 18 mins
Last updated: 06 Oct 2020
Published: 06 Oct 2020

4.1 Therapeutic indications

Symptomatic control and reduction of growth hormone (GH) and IGF-1 plasma levels in patients with acromegaly who are inadequately controlled by surgery or radiotherapy. Octreotide is also indicated for acromegalic patients unfit or unwilling to undergo surgery, or in the interim period until radiotherapy becomes fully effective.

Relief of symptoms associated with functional gastro-entero-pancreatic (GEP) endocrine tumours,e.g. carcinoid tumours with features of carcinoid syndrome (see section 5.1).

Octreotide is not an anti-tumour therapy and is not curative in these patients.

Prevention of complications following pancreatic surgery.

Emergency management to stop bleeding and to protect from re-bleeding owing to gastro-oesophageal varices in patients with cirrhosis. Octreotide is to be used in association with specific treatment such as endoscopic sclerotherapy.

Treatment of Thyroid Stimulating Hormones (TSH)-secreting pituitary adenomas:

- when secretion has not normalised after surgery and/or radiotherapy

- in patients in whom surgery is inappropriate

- in irradiated patients, until radiotherapy is effective.

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Drugs appearing in this section are approved by UK Medicines & Healthcare Products Regulatory Agency (MHRA), & the European Medicines Agency (EMA).