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Transplantation Learning Zone
Declaration of sponsorship Novartis Pharma AG

Immunosuppression

Declaration of sponsorship Novartis Pharma AG
Read time: 180 mins
Last updated:16th Apr 2021
Published:16th Apr 2021
Are you aware of the latest strategies and regiments for immunosuppression in renal transplantation? Learn about existing regimens through to the latest targeted treatments available, and read the results of the TRANSFORM study, the largest-ever prospective trial of de novo kidney transplant recipients.

Overview

 

In transplantation, immunosuppressants are used to prevent the body from recognising or attacking the new organ via various immune responses. 

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Induction therapy

Biological agents

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Calcineurin inhibitors

Cyclosporine versus tacrolimus

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Corticosteroids

Corticosteroids have been a part of maintenance immunosuppressive regimes for decades.

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Anti-metabolites

The anti-metabolite (DNA synthesis inhibitor) azathioprine (a prodrug of 6-mercaptopurine) in combination with corticosteroids was the first immunosuppressive regimen used.

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mTOR inhibitors

Sirolimus versus everolimus

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Biologics

The chimeric anti-CD25 monoclonal antibodies daclizumab and basiliximab are used for induction therapy in solid organ transplantation.

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References

  1. Shrestha B, Haylor J, Raftery A. Historical perspectives in kidney transplantation: An updated review. Progress in Transplantation. 2015;25(1). doi:10.7182/pit2015789.
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