Purpose: We investigated the effects of long-term testosterone therapy on urinary and sexual function, and quality of life in hypogonadal men.
To evaluate the effects of testosterone-replacement therapy (TRT) on prostate health indicators in hypogonadal men.
Obese men commonly have reductions in circulating testosterone and report symptoms consistent with androgen deficiency.
Testosterone treatment led to reductions in leptin beyond those achieved by diet-associated weight loss. Testosterone treatment may reduce leptin resistance in obese men.
Conflicting evidence exists for the association between testosterone replacement therapy and mortality and cardiovascular events.