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Aggressive Behaviors in Alzheimer Disease and Mild Cognitive Impairment: Systematic Review and Meta-Analysis.
Objective: We aim to estimate the risk of perpetrating aggression in Alzheimer disease (AD) and mild cognitive impairment (MCI) by conducting a systematic review and meta-analysis of primary studies.
Association between polypharmacy and dementia - A systematic review and metaanalysis.
Objective: The association between polypharmacy and dementia is controversial. This systematic review and meta-analysis aims to summarize existing literature concerning the association between polypharmacy and dementia.
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals).
Hospitalisation rates and predictors in people with dementia: a systematic review and meta-analysis.
Background: Hospitalisation is often harmful for people with dementia and results in high societal costs, so avoidance of unnecessary admissions is a global priority. However, no intervention has yet reduced admissions of community-dwelling people with dementia.
Review of Current Strategies for Delivering Alzheimer's Disease Drugs across the Blood-Brain Barrier.
Effective therapy for Alzheimer's disease is a major challenge in the pharmaceutical sciences. There are six FDA approved drugs (e.g., donepezil, memantine) that show some effectiveness; however, they only relieve symptoms.
Lecanemab accepted for review by Canadian authorities to treat early Alzheimer's disease.- Eisai/Biogen
Eisai and Biogen announced that Canadian health authorities have accepted for review an application for their anti-amyloid beta antibody lecanemab for the treatment of early Alzheimer’s disease (AD) with confirmed amyloid pathology in the brain.
Relationship between long non-coding RNAs and Alzheimer's disease: a systematic review.
Alzheimer disease (AD), is a typical progressive and destructive neurodegenerative disease. It is the leading cause of senile dementia that is mainly represented as neurocognitive symptoms, including progressive memory impairment...