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Psoriasis Academy

Psoriasis Treatment

Read time: 200 mins
Last updated:20th Apr 2021

Learn about the inflammatory pathways involved in disease initiation and progression and the latest updates on treatments for moderate-to-severe psoriasis, including:

  • Psoriasis pathophysiology in our expert interview with Professor Stefano Piaserico
  • Key clinical trial results of available systemic and biologic treatments
  • Recent long-term efficacy and safety data with Professor Diamant Thaçi
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Inflammatory pathways

Psoriasis is more than a dermatological disorder. It is a chronic immune-mediated disease in which genetically susceptible individuals develop cutaneous inflammation and keratinocyte hyperproliferation (Nestle et al., 2009; Boehncke & Schön, 2015).

Psoriasis is associated with epidermal thickening and keratinocyte hyperproliferation. As a result, the skin becomes inflamed and has raised plaques with silvery scales, which can cover large areas of the body (Nestle et al., 2009; Boehncke & Schön, 2015; Palfreeman et al., 2013).

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Systemic and biologic treatments

For patients with milder disease, first-line psoriasis treatment often involves topical therapies including corticosteroids, vitamin D3 analogues, and combination products. However, patients with moderate to severe and refractory symptoms may be candidates for systemic therapy (Kim et al., 2017).

In a survey conducted in the United States, Canada, France, Germany, Italy, Spain, and the United Kingdom, dermatologists reported that among patients with moderate to severe psoriasis, approximately 75% of patients were receiving topical therapy, 20% of patients were receiving conventional oral therapy and 20% of patients were receiving biologics (Feldman et al., 2016a). 

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Key research and clinical data

Psoriasis-related publications have grown substantially since 1960 and recent discoveries have paved the way for future research. Although research topics have expanded and diversified, the goal of research has remained to better understand psoriasis and its treatment to benefit patients living with the disease (Sako, 2016).

The ever-changing psoriasis therapeutic landscape makes it particularly important to not only acknowledge the efficacy and safety of treatments in clinical trials, but also to consider results from long-term registry-based observational studies (Altenburg et al., 2018).

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Access content from credible sources, including expert-led commentary, videos, podcasts, and webinars as well as clinical trials, treatment information and guidelines 

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Register for free access to this exclusive healthcare learning resource


Why sign up with Medthority?

Develop your knowledge with our disease and condition focused Learning Zones

Access content from credible sources, including expert-led commentary, videos, podcasts, and webinars as well as clinical trials, treatment information and guidelines 

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Register for free access to this exclusive healthcare learning resource


Why sign up with Medthority?

Develop your knowledge with our disease and condition focused Learning Zones

Access content from credible sources, including expert-led commentary, videos, podcasts, and webinars as well as clinical trials, treatment information and guidelines 

Personalised dashboard providing updates and recommendations for content within your areas of interest

Welcome: