This site is intended for healthcare professionals
Oral Anticoagulation Reversal Learning Zone

39th International Symposium on Intensive Care and Emergency Medicine 2019

In this video series, find the latest information on the fundamental principles of coagulopathy and updates to the European guidelines on the management of major bleeding following trauma.

In March 2019, experts from around the globe travelled to Brussels for the 39th International Symposium on Intensive Care and Emergency Medicine (ISICEM). Attracting more than 6,200 participants, ISICEM is dedicated to sharing the latest developments in critical care and emergency medicine. Video footage from the CSL Behring sponsored satellite symposium, featuring topics such as the emergency reversal of anticoagulation and anticoagulation inhibition with prothrombin complex concentrate (PCC) and vitamin K, can be found below.

Meet the expert

Donat Spahn is a Professor of Anaesthesiology and Chairman of the Institute of Anaesthesiology at University Hospital Zürich, Switzerland.

The elements of trauma induced coagulopathy

Professor Donat Spahn discusses the elements of trauma induced coagulopathy (TIC) from pre-existing conditions and co-morbidities to tissue damage and haemorrhage and the eventual critical reduction of coagulation factors, such as fibrinogen, through various mechanisms.

Coagulopathy is frequent after major trauma and fibrinogen becomes critically reduced first in many trauma patients. Watch to discover the elements of TIC from initial tissue damage to the critical reduction of coagulation factors.

Key recommendations in the reversal of antithrombotic agents

In this video Professor Donat Spahn suggests that patient management should be based on a multidisciplinary, evidence-based treatment protocol. He also summarises the key recommendations for the reversal of antithrombotic agents in patients with ongoing bleeding including the combination of PCC and vitamin K for anticoagulation.

A systematic review has previously shown that PCC provides more rapid and complete factor replacement than FFP. Watch this video to find out the key recommendations for the reversal of antithrombotic agents such as the early use of PCC and intravenous vitamin K.

Welcome: