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Phase III DERBY and OAKS studies of Empaveli show mixed results in geographic atrophy.- Apellis Pharma

Read time: 1 mins
Last updated:11th Sep 2021
Published:11th Sep 2021
Apellis Pharmaceuticals reported top-line results from the Phase III DERBY and OAKS studies evaluating intravitreal Empaveli (pegcetacoplan), an investigational targeted C3 therapy, in 1,258 adults with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Monthly and every-other-month treatment with pegcetacoplan met the primary endpoint in OAKS, significantly reducing GA lesion growth by 22% (p=0.0003) and 16% (p=0.0052), respectively, compared to pooled sham at 12 months. DERBY did not meet the primary endpoint, showing a reduction in GA lesion growth of 12% (p=0.0528) and 11% (p=0.0750) with monthly and every-other-month treatment, respectively, compared to pooled sham at 12 months.
Condition: Geographic Atrophy/AMD
Type: drug
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