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Molecular diagnostics for RET inhibition in NSCLC and thyroid cancers

Patient stratification

Read time: 50 mins
Last updated:10th Sep 2021
Published:10th Sep 2021

Why is patient stratification important for the treatment of RET-altered cancer?

  • Learn about common RET alterations in non-small cell lung cancer (NSCLC) and thyroid cancer
  • Discover the challenges in stratifying patients with RET-altered cancers
  • Listen to expert insights from specialist practitioners about how these challenges can be addressed

Importance of patient stratification for RET inhibition

In the following video Professor Fernando Lopez-Rios from San Pablo CEU University in Madrid, Spain, highlights the importance of molecular testing for rearranged during transfection (RET) gene fusions in non-small cell lung cancer (NSCLC) and thyroid cancers, and the real-world challenges of molecular testing.

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RET alterations in NSCLC

In the following video Dr Alexander Drilon, a non-small cell lung cancer (NSCLC) expert, outlines how rearranged during transfection (RET) gene alteration status impacts on treatment decisions for patients with NSCLC.

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RET alterations in thyroid cancer

Thyroid cancer comprises differing subtypes, many of which are associated with rearranged during transfection (RET) gene alterations1.

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Emerging challenges in stratifying patients

Real-world challenges of thyroid cancer management: patient stratification and molecular testing for RET alterations

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Real-world challenges of NSCLC management: patient stratification and molecular testing for RET alterations

2

Experts Dr Alexander Drilon and Dr Lori Wirth describe the challenges associated with stratifying patients for rearranged during transfection (RET) inhibition treatment in both thyroid cancer and non-small cell lung cancer (NSCLC).

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References

  1. Salvatore D, Santoro M, Schlumberger M. The importance of the RET gene in thyroid cancer and therapeutic implications. Nature Reviews Endocrinology. 2021;17(5):296–306.
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