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Molecular diagnostics for RET inhibition in NSCLC and thyroid cancers

Molecular testing

Read time: 80 mins
Last updated:10th Sep 2021
Published:10th Sep 2021

Learn more about the molecular testing techniques used to identify RET alterations in patients.

  • Explore current diagnostic technology, such as next-generation sequencing (NGS), and understand the types of samples needed
  • Learn about the interpretation of results
  • Realise the strengths and limitations of different molecular testing techniques

Testing techniques

Professor Fernando Lopez-Rios, professor of Pathology and Molecular Pathology at San Pablo CEU University in Madrid, Spain, discusses molecular testing techniques that can detect rearranged during transfection (RET) gene alterations.

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Sample requirements

In the following videos, Professor Fernando Lopez-Rios details the journey of the clinical sample for molecular testing and sample requirements in both non-small cell lung cancer (NSCLC) and thyroid cancer.

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Interpreting results

Professor Fernando Lopez-Rios, Dr Alexander Drilon and Dr Lori Wirth discuss how to interpret molecular testing results in non-small cell lung cancer (NSCLC) and thyroid cancers.

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Access to testing

Despite the advent of next-generation sequencing (NGS), traditional techniques such as fluorescence in situ hybridisation (FISH) and quantitative polymerase chain reaction (qPCR) are still widely used in the clinic16.

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References

  1. Leukemia and Lymphoma Society: Cancer Molecular Profiling. https://www.lls.org/sites/default/files/National/USA/Pdf/Publications/FS31_Cancer_Molecular_Profiling.pdf. Accessed 22 July 2021.
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