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Journal

Ultrasound-targeted microbubble destruction: toward a new strategy for diabetes treatment.

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Published:25th Mar 2020
Author: Mozafari M, Shimoda M, Urbanska AM, Laurent S.
Ref.:Drug Discov Today. 2015 Nov 29. pii: S1359-6446(15)00445-6.
DOI:10.1016/j.drudis.2015.11.010.

Ultrasound-targeted microbubble destruction (UTMD) is a promising technique with an immense target-specific gene delivery potential deep inside the human body. The potential of this technique has recently been confirmed for diabetic patients. This technology allows the genes to transfer specifically into the inefficient pancreas using ultrasound energy without viral vector utilization. It has been speculated that this idea and the advent of modern gene therapy techniques could result in significant future advances. Undoubtedly, this strategy needs further investigation and many critical questions have to be answered before it can be successfully advanced. Herein, we introduce the salient features of this approach, the hurdles that must be overcome, the hopes associated with it and practical constraints to develop this method for diabetes treatment.

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