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Serum IgA/C3 Ratio Predicts progression of IgA Nephropathy

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Published:25th Mar 2020
Source: Nephrology
Background The serum IgA/C3 ratio has been shown to be a good predictor of histological lesions and prognosis for patients with IgA nephropathy (IgAN) in Japanese. But its validity in Chinese population is unclear. We sought to explore the long-term outcomes of IgAN, its clinical and histopathological predictors in Chinese patients. In particular, the role of serum IgA/C3 ratio in the course of IgAN was addressed. Methods A total of 217 biopsy-diagnosed IgAN patients were recruited into this prospective cohort with a mean follow-up of 36(25th-75th percentile, 27-48) months. Sociodemographics, serum IgA/C3 level, other clinical examinations, and Lee's histological grade were measured. The patients with a decline of eGFR> 50% or developing End-stage renal disease (ESRD) were defined as progression. Results A total of 21 patients were found to progress (9.7%). In multivariate analysis, renal end point of IgAN was significantly predicted by Proteinuria ?1 g/day (RR = 2.65, 95% CI 1.01-7.68), hypertension (RR = 3.15, 95% CI 1.07-9.29), higher Lee's histological grade (RR = 4.67, 95% CI 1.43-15.25), and serum IgA/C3 ratio?3.32 (RR = 4.31, 95% CI 1.33-13.96). Conclusion A proportion of patients with IgAN developed end stage renal disease in Chinese. In addition to some traditional risk factors, we also confirmed that IgA/C3 ratio is a useful predictor of poor outcomes of IgAN in Chinese patients.

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