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Physical Exercise Ameliorates The Toxic Effect Of Fluoride On The Insulin-Glucose System

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Published:25th Mar 2020
Daily intake of water with fluoride concentration higher than 1.5 mg l-1 produces insulin resistance. On the other hand, physical activity increases insulin sensitivity in the muscle. Therefore, the aim of this study was to evaluate the effect of physical activity on insulin resistance in rats treated with chronic ingestion of sodium fluoride (NaF). Sprage Dawley rats were divided into three groups (n=10 per group): Control (drinking water without NaF), NaF (drinking water with NaF 15 mg l-1 for 30 days) and Exercise (daily running on a treadmill during 60 minutes at 2,25 m min-1 and drinking water with NaF 15 mg l-1 for 30 days). Insulin resistance was evaluated with HOMA-IR index using fasting plasma levels of glucose and insulin. Insulin resistance increased in animals treated with 15 mg l-1 NaF in drinking water. A decrease in insulin resistance was observed in rats that performed physical activity and drank water with 15 mg l-1 NaF, also exercise group showed an increase in the amount of bone fluoride. The variation in the HOMA-IR values could be consequence of variation in the sensibility of tissues to insulin or decrease in plasma fluoride levels due to bone fluoride intake. These findings indicate that the performance of daily physical activity could reduce the negative effects of the chronic ingestion of NaF on glucose homeostasis.

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