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Journal

Inflammatory cytokines in general and central obesity and modulating effects of physical activity

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Published:25th Mar 2020
Author: Schmidt FM, Weschenfelder J, Sander C, Minkwitz J, Thormann J, Chittka T, Mergl R, Kirkby KC, Fa�hauer M, Stumvoll M, Holdt LM, Teupser D, Hegerl U, Himmerich H.
Source: PLoS One
Ref.:PLoS One. 2015 Mar 17;10(3):e0121971. eCollection 2015.
DOI:10.1371/journal.pone.0121971.

Context: Chronic systemic inflammation in obesity originates from local immune responses in visceral adipose tissue. However, assessment of a broad range of inflammation-mediating cytokines and their relationship to physical activity and adipometrics has scarcely been reported to date.
Objective: To characterize the profile of a broad range of pro- and anti-inflammatory cytokines and the impact of physical activity and energy expenditure in individuals with general obesity, central obesity, and non-obese subjects.
Conclusions: Results confirm up-regulation of certain pro- and anti-inflammatory cytokines in obesity. In obese subjects, physical activity may lower levels and thus reduce pro-inflammatory effects of cytokines that may link obesity, insulin resistance and diabetes.

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