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Changing thresholds and incidence of antibiotic treatment of cystic fibrosis pulmonary exacerbations, 1995�2005

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Published:25th Mar 2020
Background: Increased chronic therapy use and improved cystic fibrosis (CF) patient health should be accompanied by reduced pulmonary exacerbation-associated antibiotic treatment incidence. Methods: Treatment incidence rates and associated sign/symptom scores from 1995�2005 were studied in Epidemiologic Study of CF patients by route (�IV) and age (<6, 6�12, 13�17, ?18years). results: overall treatment incidence rate fell 0.0165 events patient-year year (p=".006);" iv incidence fell 0.0179 (p><.001). non-iv incidence increased in children ?12years (p?.002) while significantly decreasing in older patients. mean iv (p=".046)" and non-iv (p=".004)" treatment-associated clinical scores decreased in children><6years. non-iv (but not iv) clinical scores decreased in older patients. conclusions: iv incidence fell for all ages from 1995�2005; non-iv incidence increased in patients ?12years and fell in others. average clinical treatment thresholds fell in children><6years; iv thresholds were unchanged in older patients; non-iv thresholds fell for patients ?13years. decreases in treatment incidence were likely partially offset by lower treatment thresholds.>

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