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High-risk prostate cancer: the role of surgical management

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Published:1st Jun 2016
Author: Morlacco A, Karnes RJ.
Availability: Free full text
Ref.:Crit Rev Oncol Hematol. 2016 Jun;102:135-43.
DOI: 10.1016 j.critrevonc.2016.04.011.

High-risk prostate cancer (HR Pca) is a highly heterogeneous disease from a biological and clinical standpoint, and it carries a significant chance of morbidity and mortality. Despite the impact of PSA screening, a significant number of men continue to present with high risk disease and need adequate management: clinical evidence shows that a considerable fraction on men with HR PCa can be actually cured with either uni- or multi-modality approaches. Surgical treatment, once considered unfeasible in this setting, is acquiring more and more diffusion in modern clinical practice. Herein we discuss the main treatment strategies for high-risk prostate cancer, providing an expert opinion on the role of surgical management and its outcomes in the most recent literature.

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