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  • The dark side of regulatory T cells in psoriasis.

The dark side of regulatory T cells in psoriasis.

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Published:1st Sep 2011
Author: Soler DC, McCormick TS.
Availability: Free full text
Ref.:J Invest Dermatol. 2011 Sep;131(9):1785-6.

AbstractPsoriasis is a hereditary disease elicited by chronic activation of cutaneous T cells. Delineating the mechanistic interplay of the cell subsets involved is key to developing the next generation of effective treatments. In this issue, Bovenschen et al. report that regulatory T cells maintain a fine balance between the transcription factors Foxp3 and RORγt. In patients with psoriasis, Tregs readily turn into IL-17-expressing cells, thus potentially perpetuating the inflammatory process that characterizes the disease. Results demonstrating that the histone/protein deacetylation inhibitor trichostatin A can block this conversion suggest that an epigenetic modification may underlie regulatory T-cell plasticity.

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