This site is intended for healthcare professionals
Journals
  • Home
  • /
  • Journals
  • /
  • Non-Hodgkin lymphoma
  • /
  • The molecular pathogenesis of B-cell non-Hodgkin l...
Journal

The molecular pathogenesis of B-cell non-Hodgkin lymphoma.

Read time: 1 mins
Published:9th Jun 2015
Author: Blombery PA, Wall M, Seymour JF.
Availability: Free full text
Ref.:Eur J Haematol. 2015 Oct;95(4):280-93.
DOI:10.1111/ejh.12589.

The B-cell non-Hodgkin lymphomas (B-NHL) are a diverse group of haematological malignancies which arise from the mature B-lymphocyte compartment. Recently, our understanding of the molecular pathogenesis of these disorders has greatly increased due to technological advances such as high-throughput DNA sequencing techniques. A paradigm of B-NHL pathogenesis has emerged where the normal genetic processes that are central to generating B-cell receptor diversity (somatic hypermutation and class switch/VDJ recombination) also drive the genesis of large-scale, chromosomal-level genetic lesions and smaller-scale gene-level mutations to produce the malignant phenotypes observed. Whilst a significant degree of genetic heterogeneity exists within each B-NHL subtype, the genetic lesions present within each subtype show a degree of convergence on common intracellular signalling, epigenetic and cell cycle pathways. This convergence gives an insight into the key oncogenic drivers of specific B-NHL subtypes and potential targets for therapeutic intervention. This review covers the current understanding of the causative genetic processes of B-NHL, the associated driving molecular lesions and the implications of these findings for the treatment of this group of disorders.

 

Read abstract on library site

Access full article