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The potential of ixazomib, a second-generation proteasome inhibitor, in the treatment of multiple myeloma.

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Published:1st Jul 2017
Author: Brayer J, Baz R.
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Ref.:Ther Adv Hematol. 2017;8(7):209-220.

The therapeutic armamentarium for multiple myeloma has recently benefited from the addition of several new agents (including second-generation proteasome inhibitors, monoclonal antibodies and histone deacetylase inhibitors). This review will focus on ixazomib, an orally bioavailable second-generation proteasome inhibitor. Specifically, we will review the preclinical data, clinical trial experience, potential indications as well as unanswered questions pertaining to this new agent in multiple myeloma.


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