This site is intended for healthcare professionals
Journals
  • Home
  • /
  • Journals
  • /
  • Diabetes
  • /
  • The potential effect of ultra-long insulin deglude...
Journal

The potential effect of ultra-long insulin degludec on glycemic variability.

Read time: 1 mins
Published:30th Jun 2017
Author: Rodacki M, Carvalho RM, Zajdenverg L.
Availability: Pay for access, or by subscription
Ref.:Diabetes Res Clin Pract. 2017;133:92-103.
DOI:10.1016/j.diabres.2017.06.003

Despite the therapeutic advances in the treatment of diabetes, metabolic control instability due to glycemic variability (GV) is frequently observed in patients with diabetes on intensive insulin therapy and is associated with hyperglycemic peaks and hypoglycemic episodes. Hyperglycemia associated with GV has been implicated in the development of chronic complications due to its pro-oxidative consequences. On the other hand, hypoglycemia can be associated with increased cardiovascular risk secondarily to adrenergic activation. The ultra-long-acting insulin analogue, insulin degludec (IDeg), presents a flat and stable glucose-lowering effect both in Type 1 and Type 2 diabetes patients. In pharmacodynamic studies, IDeg has been associated with a lower variability in its insulin action than other alternatives for basal insulin, which might have clinical advantages for the stability of the glycemic control. The main objective of this review is to present pharmacological and clinical data regarding the efficacy and safety of IDeg for the treatment of diabetes focusing on its effects on GV and on hypoglycemia frequency.

 

Read abstract on library site

Access full article