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Hepatic-ischemia reperfusion injury is associated with acute kidney injury following donation after brain death liver transplantation

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Published:25th Mar 2020

Donation after Cardiac Death liver transplant recipients have an increased frequency of acute kidney injury. This suggests that hepatic ischemia-reperfusion injury may play a critical role in the pathogenesis of acute kidney injury after liver transplantation. The aim of this single-center study was to determine if hepatic ischemia-reperfusion injury, estimated by peak peri-operative serum AST, is associated with AKI following donation after Brain Death (DBD) liver transplantation. 296 patients received 298 DBD liver transplants January 2007-June 2011. The incidence of acute kidney injury was 35.9%. Acute kidney injury was a risk factor for chronic kidney disease (p=0.037) and mortality (p=0.002). On univariate analysis peak AST correlated with peak creatinine (p<0.001) and peak change in creatinine from baseline (p><0.001). peak ast was higher in acute kidney injury patients (p><0.001). the incidence of acute kidney injury in patients with a peak ast of><1500 u l, 1500-2999 u l and ?3000 u l was 26.1%, 39.8% and 71.2%, respectively (p><0.001). on multiple logistic regression analysis peak ast was independently associated with the development of acute kidney injury (p><0.001). in conclusion, hepatic ischemia-reperfusion injury demonstrates a strong relationship with peri-operative acute kidney injury in dbd liver transplant recipients.></0.001).></0.001).></1500></0.001).></0.001).></0.001)>


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